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Application Note

Streamlined Reaction Monitoring with the QM-125 Benchtop NMR: Flow-Based Simplicity & Automation

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Overview

The QM-125 offers practical, real-time NMR reaction monitoring with an easy automation-ready workflow. Its 125 MHz performance and flexible sample delivery enable high-quality kinetic insights without complex setups. This application note on the reaction monitoring of a Fischer esterification demonstrates how it provides reliable data collection through baseline-resolved and simple integration. This modern NMR solution enhances continuous analysis and meets the demands for automated, data-driven reaction development.

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Application Note Highlights

  • Real-time reaction monitoring by benchtop NMR at 125 MHz

  • Monitoring a Fischer esterification reaction of benzoic acid

  • Detection of a reaction intermediate by benchtop NMR

  • No deuterated solvents, cryogens, or specialized probe required

  • High shim stability and field homogeneity through experiment

  • Sample-delivery-by-flow without 5 mm NMR tubes

  • Example automation setup using pumps and valves

  • Routine stop-flow data acquisition every 5 min for 3 hrs.

  • Automation via Python and QM Control software​

  • Availability of example scripts and technical support

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