Application Note

Overview

This application note demonstrates kinetic profiling of a second-order Diels–Alder reaction using benchtop NMR at 125 MHz with the QM-125. It demonstrates real-time reaction monitoring, quantitative NMR analysis, and rate constant determination all done without deuterated solvents or complicated sample handling. For academic teaching laboratories, this experiment exemplifies how the QM-125 aligns with ACS learning outcomes by reinforcing kinetics, mechanism, and spectroscopic analysis through hands-on data interpretation. In industrial research environments, the same capabilities support rapid reaction monitoring, small-scale kinetic analysis, and method development directly on the bench, enabling faster decision-making without reliance on high-field NMR facilities.

Regardless, the QM-125 provides a cost-effective and accessible platform for integrating quantitative NMR into undergraduate instruction, graduate research, and pharmaceutical workflows.

​​

Application Note Highlights​​

• Second-order Diels–Alder kinetics measured at 125 MHz

• Real-time reaction monitoring without deuterated solvents

• Quantitative NMR for rate constant determination

• ACS-aligned teaching experiment for organic chemistry

• Supports undergraduate and graduate-level instruction

• Walk-up operation enables back-to-back student use

• Flow-based reaction monitoring on the benchtop

• Cost-effective alternative to high-field NMR facilities

• Industry-relevant kinetics and method development

• Clean, well-resolved spectra on a benchtop system