NMR for Everyone
Overview
The QM-125 125 MHz benchtop NMR enables fast, reliable PLGA copolymer analysis directly in the laboratory—without the cost or complexity of high-field NMR. This application note demonstrates how benchtop NMR can accurately quantify lactic acid (LA) and glycolic acid (GA) content in 50:50 PLGA, providing essential data for polymer characterization, drug-delivery research, and quality control. With high spectral resolution, narrow linewidths, and minimal sample requirements, the QM-125 delivers quantitative NMR performance suitable for regulated workflows, material verification, and routine polymer analysis. This resource is ideal for scientists and manufacturers seeking a modern, accessible approach to PLGA composition testing and copolymer QC.
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Application Note Highlights​​
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Quantifies LA:GA ratios in 50:50 PLGA using 125 MHz NMR
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Structural assignment of LA and GA copolymer units
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Baseline-resolved LA and GA signals enable confident integration
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Demonstrates mol%/wt% calculations for copolymer
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Excellent agreement with sample COA by qNMR assay
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Minimal sample volume simplifies routine polymer analysis demands
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High-resolution performance enhances QA/QC reliability
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Supports formulation, degradation, and and PAT monitoring
